objective(s): this study aimed to investigate the role and the possible mechanisms involved in the immunoregulation of experimental periodontitis by th17/treg. materials and methods: experimental periodontitis was established by silk thread ligation with porphyromonasgingivalis daubing in the bilateral maxillary second molar of male sprague-dawley (sd) rats. alveolar bones were scanned by micro...

Objectives: The purpose of this study was to evaluate the effect of low dose doxycycline and atorvastatin on gingival inflammation and alveolar bone loss in an experimental model of periodontitis in rats. Methods: Forty male Sprague Dawley rats were divided into four study groups as follows: (I) experimental periodontitis control, (II) rats with periodontitis treated with low dose atorvastatin...

BACKGROUND The involvement of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts inactive glucocorticoids into active glucocorticoids intracellularly, in metabolic diseases and chronic inflammatory diseases has been elucidated. We recently reported that an increase in 11β-HSD1 expression was associated with chronic periodontitis in humans irrespective of obesity. To further clar...

Although the clinical relationship between periodontitis and diabetes mellitus (DM) is well established, few investigations have focused on the immunoinflammatory responses in sites with periodontitis in subjects with DM. Because of the potential association between periodontitis and diabetes, the aim of this study was to examine the serum levels of IL17 in diabetic and non-diabetic rats with e...

OBJECTIVE Pentraxin 3 (PTX3), newly discovered inflammation marker, is a member of acute-phase proteins. The hypothesis, synthesis of gingival tissue and serum PTX-3 increases in the experimental periodontitis model (with 10-day and 40-day periods), was tested by detecting gingival tissue and serum PTX-3 levels in rats with experimental periodontitis. METHODS Thirty rats were randomly divided...

Periodontal diseases are one of the most common complex infections in humans and many other mammals. Infectious agents causing periodontitis are primarily periodontopathogenic bacteria, but disease pathogenesis and progression are immune-mediated. Local inflammation is well characterized, and experimental animal models of periodontitis have also provided mostly consistent data on systemic infla...

The purpose of the study was to histologically analyse transition from pulpitis to periapical periodontitis on dog's teeth. Pulps of mandibular premolars (37 roots) were exposed using a low-speed handpiece. Teeth were left open to the oral environment for 20, 35, 50 and 65 days. After the experimental period animals were sacrificed. Undemineralised teeth with surrounding bone, embedded in methy...

Objective: This study is to investigate the effect of hyperbaric oxygen (HBO) on HIF-1α expression in rat experimental periodontitis with psychological stress. Methods: One hundred and twenty male special pathogenfree Wistar rats were randomly divided into four groups: normal control group, experimental periodontitis group, psychological stress stimulation group, and periodontitis model with st...

A relationship between periodontal disease and atherosclerosis has been suggested by epidemiological studies. Ligature-induced experimental periodontitis is an adequate model for clinical periodontitis, which starts from plaque accumulation, followed by inflammation in the periodontal tissue. Here we have demonstrated using a ligature-induced periodontitis model that periodontitis activates mon...